Psychometric analysis of the UK Health and Safety Executive's Management Standards work-related stress Indicator Tool

In the UK the Health & Safety Executive (HSE) Management Standards (MS) work-related stress Indicator Tool is the standard measure that organizations use to assess workplace stress. However, no in-depth analysis has been performed to test the psychometric properties of this scale. The current study is the first to examine the factor structure of the HSE MS Indicator Tool using organizational-level data. Data collected from 39 organizations (N = 26,382) was used to perform a first-order Confirmatory Factor Analysis (CFA) on the original 35-item seven-factor measurement scale. The results showed an acceptable fit to the data for the instrument. A second-order CFA was also performed to test if the Indicator Tool contains a higher order uni-dimensional measure of work-related stress. These findings also revealed an acceptable fit to the data, suggesting that it may be possible to derive a single measure of work-related stress

An algorithmic method for functionally defining regions of interest in the ventral visual pathway

In a widely used functional magnetic resonance imaging (fMRI) data analysis method, functional regions of interest (fROIs) are handpicked in each participant using macroanatomic landmarks as guides, and the response of these regions to new conditions is then measured. A key limitation of this standard handpicked fROI method is the subjectivity of decisions about which clusters of activated voxels should be treated as the particular fROI in question in each subject. Here we apply the Group-Constrained Subject-Specific (GSS) method for defining fROIs, recently developed for identifying language fROIs (Fedorenko et al., 2010), to algorithmically identify fourteen well-studied category-selective regions of the ventral visual pathway (Kanwisher, 2010). We show that this method retains the benefit of defining fROIs in individual subjects without the subjectivity inherent in the traditional handpicked fROI approach. The tools necessary for using this method are available on our website (http://web.mit.edu/bcs/nklab/GSS.shtml).Ellison Medical Foundatio

04351 Summary -- Spatial Representation: Discrete vs. Continuous Computational Models

Topological notions and methods are used in various areas of the physical sciences and engineering, and therefore computer processing of topological data is important. Separate from this, but closely related, are computer science uses of topology: applications to programming language semantics and computing with exact real numbers are important examples. The seminar concentrated on an important approach, which is basic to all these applications, i.e. spatial representation

04351 Abstracts Collection -- Spatial Representation: Discrete vs. Continuous Computational Models

From 22.08.04 to 27.08.04, the Dagstuhl Seminar 04351 ``Spatial Representation: Discrete vs. Continuous Computational Models\u27\u27 was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available

Understanding the psychological mechanisms of return to sports readiness after anterior cruciate ligament reconstruction.

Purpose The psychological response to an Anterior Cruciate Ligament (ACL) injury is significant and can negatively impact return to sports outcomes. This study aimed to quantify the association between factors associated with return to sport using network analysis. Methods 441 participants who underwent primary ACL reconstruction. The 12-item ACL Return to Sport after Injury (ACL-RSI) scale was administered to all participants 12 months after surgery. Three network analyses were used to quantify the adjusted correlations between the 12 items of the ACL-RSI scale, and to determine the centrality indices of each item (i.e., the degree of connection with other items in the network). Further subgroup network analyses were conducted for those who had (n = 115) and had not returned (n = 326) to their pre-injury level of sport. Results The greatest adjusted correlation was between Q7 and Q9 (fear of re-injury and afraid of accidentally injuring knee) of the ACL-RSI (group 0.48 (95%CI [0.40 to 0.57])) across all three networks. The most important item in the network was Q12 (relaxed about sport) across all three networks. Individuals who did return to sport had greater Strength centrality for Q8 (confidence in knee, P = 0.014) compared to those who did not return to sport. Conclusion Fear of re-injury and being relaxed about playing sport were the two most important nodes in the network models that describe the return to sport readiness. The importance of knee confidence at influencing psychological readiness was greater in athletes who did return to sport compared to those who did not. Our findings provide candidate therapeutic targets that could inform future interventions designed to optimize return to sport rates in athletes post ACL reconstruction

The Genome Sequences of Three Paraburkholderia sp. Strains Isolated from Wood-Decay Fungi Reveal Them as Novel Species with Antimicrobial Biosynthetic Potential.

Three strains of fungus-associated Burkholderiales bacteria with antagonistic activity against Gram-negative plant pathogens were genome sequenced to investigate their taxonomic placement and potential for antimicrobial specialized metabolite production. The selected strains were identified as novel taxa belonging to the genus Paraburkholderia and carry multiple biosynthetic gene clusters

Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery.

The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including the antibiotics gladiolin, icosalide A, enacyloxin, and cepacin A

Thermal and Air Quality Acceptability in Buildings that Reduce Energy by Reducing Minimum Airflow from Overhead Diffusers

There is great energy-saving potential in reducing variable air volume (VAV) box minimum airflow setpoints.In the past, setpoints have been maintained at high levels because of three concerns: 1) low flows might cause the occupants draft discomfort from insufficient mixing of diffuser discharge air, 2) inability of VAV boxes to control at low flows, and 3) poor air quality resulting from a combination of poor control and insufficient diffuser mixing. It is worth examining these concerns to see whether they are justified. The controller accuracy and stability have recently been addressed by RP 1353, in which VAV boxes were found to control well at very low flow levels. The diffuser mixing issue and impact on comfort are addressed in this research project, RP 1515.RP 1515 is a combined field and laboratory study, in which occupants’ thermal comfort and air quality satisfaction is evaluated in the field under reduced minimum VAV flow rate setpoints, and the mixing performance of diffusers is measured in the laboratory. The laboratory portion was performed with co-funding from Price Industries. Additional co-funding from the California Energy Commission’s PIER program allowed us to quantify the HVAC energy savings resulting from the reduced flows in the field study buildings.

Kill and cure: genomic phylogeny and bioactivity of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles.

Burkholderia gladioli is a bacterium with a broad ecology spanning disease in humans, animals and plants, but also encompassing multiple beneficial interactions. It is a plant pathogen, a toxin-producing food-poisoning agent, and causes lung infections in people with cystic fibrosis (CF). Contrasting beneficial traits include antifungal production exploited by insects to protect their eggs, plant protective abilities and antibiotic biosynthesis. We explored the genomic diversity and specialized metabolic potential of 206 B. gladioli strains, phylogenomically defining 5 clades. Historical disease pathovars (pv.) B. gladioli pv. allicola and B. gladioli pv. cocovenenans were distinct, while B. gladioli pv. gladioli and B. gladioli pv. agaricicola were indistinguishable; soft-rot disease and CF infection were conserved across all pathovars. Biosynthetic gene clusters (BGCs) for toxoflavin, caryoynencin and enacyloxin were dispersed across B. gladioli, but bongkrekic acid and gladiolin production were clade-specific. Strikingly, 13 % of CF infection strains characterized were bongkrekic acid-positive, uniquely linking this food-poisoning toxin to this aspect of B. gladioli disease. Mapping the population biology and metabolite production of B. gladioli has shed light on its diverse ecology, and by demonstrating that the antibiotic trimethoprim suppresses bongkrekic acid production, a potential therapeutic strategy to minimize poisoning risk in CF has been identified